BAX Activation is Initiated at a Novel Interaction Site

  title={BAX Activation is Initiated at a Novel Interaction Site},
  author={Evripidis Gavathiotis and Motoshi Suzuki and Marguerite L. Davis and Kenneth Pitter and Gregory H. Bird and Samuel G. Katz and H Tu and Hyungjin Myra Kim and E. N. H. Cheng and Nico Tjandra and Loren D. Walensky},
BAX is a pro-apoptotic protein of the BCL-2 family that is stationed in the cytosol until activated by a diversity of stress stimuli to induce cell death. Anti-apoptotic proteins such as BCL-2 counteract BAX-mediated cell death. Although an interaction site that confers survival functionality has been defined for anti-apoptotic proteins, an activation site has not been identified for BAX, rendering its explicit trigger mechanism unknown. We previously developed stabilized α-helix of BCL-2… CONTINUE READING
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