BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagy.

@article{Sebti2014BAT3MP,
  title={BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagy.},
  author={Salwa Sebti and Christine Pr{\'e}bois and Esther P{\'e}rez-Gracia and Chantal Bauvy and Fabienne Desmots and Nelly Pirot and C{\'e}line Gongora and A Bach and Andrew V Hubberstey and Val{\'e}rie Palissot and Guy J. Berchem and Patrice Codogno and Laetitia K Linares and Emmanuelle Liaudet-Coopman and Sophie Pattingre},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 11},
  pages={4115-20}
}
Autophagy is regulated by posttranslational modifications, including acetylation. Here we show that HLA-B-associated transcript 3 (BAT3) is essential for basal and starvation-induced autophagy in embryonic day 18.5 BAT3(-/-) mouse embryos and in mouse embryonic fibroblasts (MEFs) through the modulation of p300-dependent acetylation of p53 and ATG7. Specifically, BAT3 increases p53 acetylation and proautophagic p53 target gene expression, while limiting p300-dependent acetylation of ATG7, a… CONTINUE READING

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