BASIGIN is a receptor essential for erythrocyte invasion by Plasmodium falciparum

  title={BASIGIN is a receptor essential for erythrocyte invasion by Plasmodium falciparum},
  author={C{\'e}cile Crosnier and Leyla Y. Bustamante and S. Josefin Bartholdson and Amy Kristine Bei and M. Theron and Makoto Uchikawa and Souleymane Mboup and Omar Ndir and Dominic P Kwiatkowski and Manoj Duraisingh and Julian C. Rayner and Gavin J. Wright},
Erythrocyte invasion by Plasmodium falciparum is central to the pathogenesis of malaria. Invasion requires a series of extracellular recognition events between erythrocyte receptors and ligands on the merozoite, the invasive form of the parasite. None of the few known receptor–ligand interactions involved are required in all parasite strains, indicating that the parasite is able to access multiple redundant invasion pathways. Here, we show that we have identified a receptor–ligand pair that is… CONTINUE READING
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