BARRIER MECHANISMS IN THE BRAIN, I. ADULT BRAIN

@article{Saunders1999BARRIERMI,
  title={BARRIER MECHANISMS IN THE BRAIN, I. ADULT BRAIN},
  author={Norman Ruthven Saunders and Mark D Habgood and K. M. Dziegielewska},
  journal={Clinical and Experimental Pharmacology and Physiology},
  year={1999},
  volume={26}
}
1. The adult brain functions within a well‐controlled (internal) environment that is separate from that of the internal environment of the rest of the body as a whole. 
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References

SHOWING 1-10 OF 89 REFERENCES
BARRIER MECHANISMS IN THE BRAIN, II. IMMATURE BRAIN
TLDR
It is shown that ‘the’ blood–brain barrier is immature in foetuses and newborns, and this results in down-regulation in the ability of the immune system to attack invading cells. Expand
Barriers in the developing brain
TLDR
Evidence is summarized that shows that proteins do not penetrate into immature brain because of specialization of barriers in the developing brain, some being unique to fetuses. Expand
Physiology of the CSF and Blood-Brain Barriers
Chemical composition and secretory nature of the fluid the blood-brain barrier the return of CSF to the blood the drainage mechanism the intracranial or CSF pressure. (Part contents).
Brain drug delivery and blood–Brain barrier transport
AbstractThis work was supported by NIH Grants A128760 and DA06748. Emily I. Yu and Sherri J. Chien skillfully prepared the manuscript.
Blood–Brain Barrier in Physiology and Medicine
No wonder you activities are, reading will be always needed. It is not only to fulfil the duties that you need to finish in deadline time. Reading will encourage your mind and thoughts. Of course,Expand
Immunocytochemical localization of immunoglobulins in the rat brain: Relationship to the blood‐brain barrier
TLDR
This study confirms the presence of IgG in the central nervous system by immunocytochemistry and demonstrates a close anatomical relationship between the distribution of this protein and the blood‐brain barrier. Expand
Cerebrospinal Fluid in Diseases of the Nervous System
TLDR
The cerebrospinal fluid CSF findings in diseases of the nervous system lumbar puncture in clinical practice are found to be related to hydrocephalus, brain oedema, pseudotumour and related disorders. Expand
Permeability of the blood brain barrier by the bradykinin agonist, RMP-7: evidence for a sensitive, auto-regulated, receptor-mediated system.
TLDR
Data support the existence of a sophisticated, responsive and tightly regulated BK system whose activity modulates the permeability of the BBB. Expand
Permeability of the normal rat brain, spinal cord and dorsal root ganglia microcirculations to immunoglobulins G
TLDR
It is demonstrated that, in the cerebral cortex and the spinal cord microcirculations, endothelial cells are a restrictive barrier against IgG while IgG are able to diffuse into the perivascular parenchyma of the pineal gland and spinal ganglia. Expand
Brain extracellular space and the sink action of cerebrospinal fluid. Measurement of rabbit brain extracellular space using sucrose labeled with carbon 14.
TLDR
These experiments were designed to test the hypothesis that a sink action of cerebrospinal fluid (CSF) removed solutes from nervous tissue ECS, resulting in substantial error in methods based upon the volume of distribution of tracer substances believed to remain confined to the ECS when these substances were introduced into brain by way of blood. Expand
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