BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis.

@article{Edwards2002BAREingIA,
  title={BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis.},
  author={Peter A. Edwards and Heidi R Kast and Andrew M Anisfeld},
  journal={Journal of lipid research},
  year={2002},
  volume={43 1},
  pages={2-12}
}
During the last three years there have been a plethora of publications on the liver X-activated receptors (LXRalpha, NR1H3, and LXRbeta, NR1H2), the farnesoid X-activated receptor (FXR, NR1H4), and the pregnane X receptor (PXR, NR1I2) and the role these nuclear receptors play in controlling cholesterol, bile acid, lipoprotein and drug metabolism. The current interest in these nuclear receptors is high, in part, because they appear to be promising therapeutic targets for new drugs that have the… CONTINUE READING