BAP31 Interacts with Sec61 Translocons and Promotes Retrotranslocation of CFTRΔF508 via the Derlin-1 Complex

@article{Wang2008BAP31IW,
  title={BAP31 Interacts with Sec61 Translocons and Promotes Retrotranslocation of CFTRΔF508 via the Derlin-1 Complex},
  author={Bing Wang and Hannah M. Heath-Engel and Donglei Zhang and Nhi Q Nguyen and David Y. Thomas and John W. Hanrahan and Gordon C. Shore},
  journal={Cell},
  year={2008},
  volume={133},
  pages={1080-1092}
}
BAP31 is an endoplasmic reticulum protein-sorting factor that associates with newly synthesized integral membrane proteins and controls their fate (i.e., egress, retention, survival, or degradation). BAP31 is itself an integral membrane protein and a constituent of several large protein complexes. Here, we show that a part of the BAP31 population interacts with two components of the Sec61 preprotein translocon, Sec61beta and TRAM. BAP31 associates with the N terminus of one of its newly… CONTINUE READING

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