BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation

  title={BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation},
  author={Angela Bononi and Carlotta Giorgi and Simone Patergnani and David G. Larson and Kaitlyn Verbruggen and Mika Tanji and Laura Pellegrini and Valentina Signorato and Federica Olivetto and Sandra Pastorino and Masaki Nasu and Andrea Napolitano and Giovanni Gaudino and Paul T Morris and Greg K Sakamoto and Laura C. Korb Ferris and Alberto Danese and Andrea Raimondi and Carlo Tacchetti and Shafi M Kuchay and Harvey I. Pass and El Bachir Affar and Haining Yang and Paolo Pinton and Michele Carbone},
BRCA1-associated protein 1 (BAP1) is a potent tumour suppressor gene that modulates environmental carcinogenesis. All carriers of inherited heterozygous germline BAP1-inactivating mutations (BAP1+/−) developed one and often several BAP1−/− malignancies in their lifetime, mostly malignant mesothelioma, uveal melanoma, and so on. Moreover, BAP1-acquired biallelic mutations are frequent in human cancers. BAP1 tumour suppressor activity has been attributed to its nuclear localization, where it… CONTINUE READING
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High Incidence of Somatic BAP1 alterations in sporadic malignant mesothelioma

  • M Nasu
  • J Thorac Oncol
  • 2015

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