BAP1 Immunohistochemistry and p16 FISH in the Diagnosis of Sarcomatous and Desmoplastic Mesotheliomas.

@article{Hwang2016BAP1IA,
  title={BAP1 Immunohistochemistry and p16 FISH in the Diagnosis of Sarcomatous and Desmoplastic Mesotheliomas.},
  author={Harry C. Hwang and Shawna M Pyott and Stephanie Perez Rodriguez and Ashlie Cindric and April Carr and Carmen Michelsen and Kim E Thompson and Christopher H Tse and Allen M. Gown and Andrew Churg},
  journal={The American journal of surgical pathology},
  year={2016},
  volume={40 5},
  pages={714-8}
}
The separation of sarcomatous and desmoplastic mesotheliomas from benign organizing pleuritis can be morphologically very difficult. Deletion of p16 (CDKN2A) by fluorescence in situ hybridization (FISH) testing appears to be a reliable marker of malignancy in mesothelial proliferations, and more recently it has been reported that, in this setting, loss of BAP1 by immunohistochemistry is only seen in malignant mesotheliomas. To determine how useful these tests are with sarcomatous and… CONTINUE READING
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