BAG5 Inhibits Parkin and Enhances Dopaminergic Neuron Degeneration

Abstract

Loss-of-function mutations in the parkin gene, which encodes an E3 ubiquitin ligase, are the major cause of early-onset Parkinson's disease (PD). Decreases in parkin activity may also contribute to neurodegeneration in sporadic forms of PD. Here, we show that bcl-2-associated athanogene 5 (BAG5), a BAG family member, directly interacts with parkin and the… (More)
DOI: 10.1016/j.neuron.2004.11.026

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