BAG3 and friends: co-chaperones in selective autophagy during aging and disease.

Abstract

There is a reciprocal change in the expression of two members of the BAG (Bcl-2-associated athanogen) family, BAG1 and BAG3, during cellular aging and under acute stress ("BAG1-BAG3-switch"). BAG3 was recently described as a mediator of a novel macroautophagy pathway that uses the specificity of heat shock protein 70 (HSP70) to misfolded proteins and also… (More)
DOI: 10.4161/auto.7.7.15844

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