BAFF regulates follicular helper t cells and affects their accumulation and interferon-γ production in autoimmunity.

@article{Coquery2015BAFFRF,
  title={BAFF regulates follicular helper t cells and affects their accumulation and interferon-γ production in autoimmunity.},
  author={Christine M. Coquery and William M. Loo and Nekeithia S. Wade and Annelise G Bederman and Kenneth S Tung and Janet E. Lewis and Henry Hess and Loren D. Erickson},
  journal={Arthritis & rheumatology},
  year={2015},
  volume={67 3},
  pages={773-84}
}
OBJECTIVE Follicular helper T (Tfh) cells are critical for the development of protective antibodies via germinal center (GC) B cell responses; however, uncontrolled Tfh cell expansion activates autoreactive B cells to produce antibodies that cause autoimmunity. The mechanisms that control Tfh cell homeostasis remain largely unknown. The aim of this study was to determine the contribution of BAFF to Tfh cell responses in autoimmunity. METHODS We analyzed the properties of Tfh cells in lupus… CONTINUE READING
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