BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma

@article{Krumbholz2005BAFFIP,
  title={BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma},
  author={Markus Krumbholz and Diethilde Theil and Tobias J Derfuss and Andreas Rosenwald and Frank Schrader and Camelia Maria Monoranu and Susan L. Kalled and Donna M. Hess and Barbara Serafini and Francesca Aloisi and Hartmut Wekerle and Reinhard Hohlfeld and Edgar Meinl},
  journal={The Journal of Experimental Medicine},
  year={2005},
  volume={201},
  pages={195 - 200}
}
We report that B cell-activating factor of the tumor necrosis factor (TNF) family (BAFF) is expressed in the normal human brain at approximately 10% of that in lymphatic tissues (tonsils and adenoids) and is produced by astrocytes. BAFF was regularly detected by enzyme-linked immunosorbent assay in brain tissue lysates and in normal spinal fluid, and in astrocytes by double fluorescence microscopy. Cultured human astrocytes secreted functionally active BAFF after stimulation with interferon… CONTINUE READING

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