BAFF enhances chemotaxis of primary human B cells: a particular synergy between BAFF and CXCL13 on memory B cells.

@article{Badr2008BAFFEC,
  title={BAFF enhances chemotaxis of primary human B cells: a particular synergy between BAFF and CXCL13 on memory B cells.},
  author={Gamal Badr and Gwenoline Borhis and Eric A. Lefevre and Nada Chaoul and Fr{\'e}d{\'e}rique Deshayes and Val{\'e}rie Dessirier and Genevi{\'e}ve Lapr{\'e}e and Andr{\'e}as Tsapis and Yolande Richard},
  journal={Blood},
  year={2008},
  volume={111 5},
  pages={2744-54}
}
B-cell-activating factor of the TNF family, (BAFF), and a proliferation-inducing ligand (APRIL) regulate B-lymphocyte survival and activation. We report that BAFF, but not APRIL, increased the chemotactic response of primary human B cells to CCL21, CXCL12, and CXCL13. The BAFF-induced increase in B-cell chemotaxis was totally abolished by blockade of BAFF-R and was strongly dependent on the activation of PI3K/AKT, NF-kappaB, and p38MAPK pathways. BAFF had similar effects on the chemotaxis of… CONTINUE READING
45 Extracted Citations
50 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 45 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 50 references

Similar Papers

Loading similar papers…