BAFF and the regulation of B cell survival.

  title={BAFF and the regulation of B cell survival.},
  author={Pascal Schneider and J. -M. Tschopp},
  journal={Immunology letters},
  volume={88 1},
The TNF family member BAFF is a fundamental survival factor for B cells. BAFF binds to three receptors, only one of which, BAFF-R, does not cross-react with the BAFF-related ligand APRIL. The survival function of BAFF on B cells is mediated mainly by BAFF-R and is particularly effective in transitional B cells. BAFF depletion leads to a considerable decrease in mature B cells, without apparent effect on B cell genesis. Consistently, BAFF overexpression results in an expanded B cell compartment… CONTINUE READING


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