BAFF and innate immunity: new therapeutic targets for systemic lupus erythematosus

@article{Vincent2012BAFFAI,
  title={BAFF and innate immunity: new therapeutic targets for systemic lupus erythematosus},
  author={Fabien B Vincent and Eric F. Morand and Fabienne Mackay},
  journal={Immunology and Cell Biology},
  year={2012},
  volume={90}
}
Recently, the B cell has emerged as a cornerstone of systemic lupus erythematosus (SLE) pathogenesis. This has been highlighted by studies of the cytokine B‐cell‐activating factor of the tumour necrosis factor (TNF) family (BAFF), a crucial factor regulating B‐cell maturation, survival and function. Overexpression of BAFF in mice leads to the development of an SLE‐like disease, independent of T cells but instead relying on innate immunity mechanisms. Moreover, BAFF has been shown to be elevated… 

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