BAF53 interacts with p53 and functions in p53-mediated p21-gene transcription.

@article{Wang2007BAF53IW,
  title={BAF53 interacts with p53 and functions in p53-mediated p21-gene transcription.},
  author={Min Wang and Chunsheng Gu and Tianyang Qi and Wen Lu Tang and Ling Wang and Shuyan Wang and Xianlu Zeng},
  journal={Journal of biochemistry},
  year={2007},
  volume={142 5},
  pages={613-20}
}
BAF53, a component of chromatin remodelling and histone acetyltransferase complexes, has been shown to be essential for cell survival in human cells and plays roles in p53-mediated gene transcription. However, the mechanism concerned in the process needs to be further explored. In this study, we show that BAF53 is involved in the repression of p53-dependent p21-gene transcription by interacting with p53 both in vivo and in vitro. Through electrophoretic mobility shift assay (EMSA) and chromatin… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
histone acetyltransferaseGene product plays role in biological processchromatin remodeling
BAF53 , a component of chromatin remodelling and histone acetyltransferase complexes , has been shown to be essential for cell survival in human cells and plays roles in p53-mediated gene transcription .
All Topics