BAF: roles in chromatin, nuclear structure and retrovirus integration.

  title={BAF: roles in chromatin, nuclear structure and retrovirus integration.},
  author={Miriam Segura-Totten and Katherine L. Wilson},
  journal={Trends in cell biology},
  volume={14 5},
Barrier-to-autointegration factor (BAF) is an essential protein that is highly conserved in metazoan evolution. BAF binds directly to double-stranded DNA, nuclear LEM-domain proteins, lamin A and transcription activators. BAF is also a host cell component of retroviral pre-integration complexes. BAF binds matrix, a retroviral protein, and facilitates efficient retroviral DNA integration in vitro through unknown mechanisms. New findings suggest that BAF has structural roles in nuclear assembly… CONTINUE READING

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