BAD partly reverses paclitaxel resistance in human ovarian cancer cells

@article{Strobel1998BADPR,
  title={BAD partly reverses paclitaxel resistance in human ovarian cancer cells},
  author={Thomas Strobel and Yu-Tzu Tai and Stanley K. Korsmeyer and StephenA. Cannistra},
  journal={Oncogene},
  year={1998},
  volume={17},
  pages={2419-2427}
}
Although paclitaxel is an important chemotherapy agent for the treatment of patients with epithelial ovarian cancer, its utility is significantly limited by the frequent development of drug resistance. Recent evidence suggests that resistance to chemotherapy may be partly related to defects in the apoptotic pathway. In this study we have investigated whether enhancement of apoptotic pathway function through stable expression of the BAD protein is capable of sensitizing human epithelial ovarian… CONTINUE READING
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