BACTERIAL TRANSFORMATION REACTIONS

@article{Austrian1952BACTERIALTR,
  title={BACTERIAL TRANSFORMATION REACTIONS},
  author={Robert Austrian},
  journal={Bacteriological Reviews},
  year={1952},
  volume={16},
  pages={31 - 50}
}
  • R. Austrian
  • Published 1 March 1952
  • Biology
  • Bacteriological Reviews
In reviewing previously the chemical nature and biologic specificity of the substance inducing transformation of pneumococcal types (31), McCarty suggested that the principles involved and the results observed in the study of this reaction have implications beyond those referable to the biology of pneumococcus. The correctness of this point of view has been borne out by the investigations of the ensuing five years. In this period the variety of cellular characters which can be controlled by… 
2 Citations
Streptococcus pneumoniae Elaborates Persistent and Prolonged Competent State during Pneumonia-Derived Sepsis
TLDR
Competent D39 bacteria propagated the competence signal through cell-to-cell contact rather than the classically described quorum-sensing mechanism and clinical pneumococcal strains of different serotypes were also able to develop natural competence during pneumonia-derived sepsis.

References

SHOWING 1-10 OF 41 REFERENCES
Variation in Pigment Production in Staphylococcus aureus
TLDR
The present study deals with an attempt to induce transformation of a white Sfaphylocuccus uureus into a chromogenic type, and results indicate that the substance has the characteristics of a desoxyribonucleic acid.
ACQUISITION OF M PROTEIN BY PNEUMOCOCCI THROUGH TRANSFORMATION REACTIONS
TLDR
It has been demonstrated that inheritable characters of three distinct pneumococcal strains can be combined within a single strain and it is suggested that acquisition of M protein through transformation reactions occurs in cells deficient in that character.
Transformation Type Specificity of H. influenzae. ∗
TLDR
The data provide another example of the control of the genetic constitution of microorganisms by specifically oriented desoxyribonucleic acids by specifically orienting them to type b and type c H. influenzae.
REVERSIBLE INACTIVATION OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES
  • M. Mccarty
  • Biology
    The Journal of experimental medicine
  • 1945
TLDR
It is concluded that inactivation of the transforming substance of Pneumococcus Type III is probably oxidative in character and depends on the formation of peroxides in the course of autoxidation of ascorbic acid or related compounds.
ADDITIVE EFFECTS OF CERTAIN TRANSFORMING AGENTS FROM SOME VARIANTS OF PNEUMOCOCCUS
  • H. E. Taylor
  • Biology, Medicine
    The Journal of experimental medicine
  • 1949
TLDR
It has proved possible to transform an extreme rough variant of pneumococcus back to the rough state by the action of the desoxyribonucleate fractions of either rough or Type III smooth pneumococci, and the findings have been interpreted as indicating that the des oxygen ribonucleic acid fraction of Type III smoother pneumonia contains two transforming principles of differing specificity, while the same fraction of rough pneumonia contains but one of these principles.
Studies on the chemical nature of the substance inducing transformation of pneumococcal types; effect of desoxyribonuclease on the biological activity of the transforming substance.
It has been shown that extremely minute amounts of purified preparations of desoxyribonuclease are capable of bringing about the complete and irreversible inactivation of the transforming substance
STEPWISE INTRATYPE TRANSFORMATION OF PNEUMOCOCCUS FROM R TO S BY WAY OF A VARIANT INTERMEDIATE IN CAPSULAR POLYSACCHARIDE PRODUCTION
TLDR
The intermediate variant D39/Int53 is avirulent for mice, forms rough colonies, and does not possess a demonstrable capsule, however, it synthesizes SSSII which is immunologically indistinguishable from that produced by fully encapsulated pneumococcus Type II, though in much smaller amount.
Further Observations on the Transformation of Type-Specific Pneumococci by In Vitro Procedures
TLDR
The transformation of pneumococci from one specific S type into other specific S types was effected through the intermediate stage of the R form in media containing vaccines prepared from cultures of heterologous S types.
Chemical nature and biological specificity of the substance inducing transformation of pneumococcal types.
In 1946, McCarty became the public face of the Avery lab. He read this paper detailing the team's work at the Annual Meeting of the American Chemical Society Symposium on Biochemical and Biophysical
The Significance of Pneumococcal Types
TLDR
In the course of the examination of sputum from cases of lobar pneumonia, observations have been made on the incidence of the chief types of pneumococci, and the antigens of certain Group IV strains appear to be closely related to that of Type II.
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