BACITRACIN: A NEW ANTIBIOTIC PRODUCED BY A MEMBER OF THE B. SUBTILIS GROUP

@article{Johnson1945BACITRACINAN,
  title={BACITRACIN: A NEW ANTIBIOTIC PRODUCED BY A MEMBER OF THE B. SUBTILIS GROUP},
  author={Balbina A. Johnson and H Anker and Frank Lamont Meleney},
  journal={Science},
  year={1945},
  volume={102},
  pages={376 - 377}
}
A new antibiotic "bacitracin" has been recovered from a strain of the B. subtilis group of organisms. It is neutral, water-soluble, non-toxic and relatively heat stable. In vitro it is active chiefly against Grampositive organisms, but the gonococcus and meningococcus are susceptible to its action. It is also active in vivo against experimentally produced hemolytic streptococcal infections in mice and gas gangrene infections in guinea pigs. Clinical use in hemolytic streptococcal and… 

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References

STUDIES ON A BACTERICIDAL AGENT EXTRACTED FROM A SOIL BACILLUS

It is shown that the bactericidal agent can be obtained in an active form free of protein, and the new purified preparations retain all the activity of the original material, both in vitro and in vivo.