BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint

@inproceedings{Swaminathan2013BACH2MN,
  title={BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint},
  author={Srividya Swaminathan and Chuanxin Huang and Huimin Geng and Zhengshan Chen and Richard C Harvey and Huining Kang and Carina Hoi Ng and Bjoern Titz and Christian Hurtz and Mohammed Firas Sadiyah and Daniel Nowak and Gabriela B. Thoennissen and Vikki Rand and Thomas G Graeber and H Phillip Koeffler and William L Carroll and Cheryl L. Willman and Andrew G Hall and Kazuhiko Igarashi and Ari M Melnick and Markus M{\"u}schen},
  booktitle={Nature Medicine},
  year={2013}
}
The B cell–specific transcription factor BACH2 is required for affinity maturation of B cells. Here we show that Bach2-mediated activation of p53 is required for stringent elimination of pre-B cells that failed to productively rearrange immunoglobulin VH-DJH gene segments. After productive VH-DJH gene rearrangement, pre-B cell receptor signaling ends BACH2-mediated negative selection through B cell lymphoma 6 (BCL6)-mediated repression of p53. In patients with pre-B acute lymphoblastic leukemia… CONTINUE READING
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