BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ.

@article{Litman2005BACH1IC,
  title={BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ.},
  author={Rachel Litman and Min Peng and Zhe Jin and Fan Zhang and Junran Zhang and Simon Powell and P. M. R. Andreassen and Sharon B Cantor},
  journal={Cancer cell},
  year={2005},
  volume={8 3},
  pages={
          255-65
        }
}
We showed in this study that cells deficient of the BRCA1-associated BACH1 helicase, also known as BRIP1, failed to elicit homologous recombination (HR) after DNA double-stranded breaks (DSBs). BACH1-deficient cells were also sensitive to mitomycin C (MMC) and underwent MMC-induced chromosome instability. Moreover, we identified a homozygous nonsense mutation in BACH1 in a FA-J patient-derived cell line and could not detect BACH1 protein in this cell line. Expression of wild-type BACH1 in this… CONTINUE READING
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