BACE1 is the major β-secretase for generation of Aβ peptides by neurons

@article{Cai2001BACE1IT,
  title={BACE1 is the major β-secretase for generation of Aβ peptides by neurons},
  author={Huaibin Cai and Yanshu Wang and D. McCarthy and H. Wen and D. Borchelt and D. Price and P. Wong},
  journal={Nature Neuroscience},
  year={2001},
  volume={4},
  pages={233-234}
}
Two β-secretases, BACE1 and BACE2, are involved in generation of Alzheimer's disease Aβ peptides. We report that secretion of Aβ peptides (Aβ1–40/42 and Aβ11–40/42) is abolished in cultures of BACE1-deficient embryonic cortical neurons, and that whereas both human and murine BACE1 can cleave either human or murine β-amyloid precursor protein (APP) at the +1 site of Aβ, cleavage at the +11 site is species specific. We establish that BACE1 is the principal neuronal protease required to cleave APP… Expand
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