BACE1 as a therapeutic target in Alzheimer's disease: rationale and current status.

@article{Evin2013BACE1AA,
  title={BACE1 as a therapeutic target in Alzheimer's disease: rationale and current status.},
  author={Genevieve Evin and Christopher Hince},
  journal={Drugs & aging},
  year={2013},
  volume={30 10},
  pages={755-64}
}
Alzheimer's disease (AD) is a neurodegenerative disease of the central nervous system that causes dementia in a large percentage of the aged population and for which there are only symptomatic treatments. Disease-modifying therapies that are currently being pursued are based on the amyloid cascade theory. This states that accumulation of amyloid β (Aβ) in the brain triggers a cascade of cellular events leading to neurodegeneration. Aβ, which is the major constituent of amyloid plaques, is a… CONTINUE READING
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