BACE1 Expression and Activity: Relevance in Alzheimer’s Disease

@article{Zacchetti2007BACE1EA,
  title={BACE1 Expression and Activity: Relevance in Alzheimer’s Disease},
  author={D. Zacchetti and E. Chieregatti and Barbara Bettegazzi and Marija Mihailovich and V{\'i}tor L. Sousa and F. Grohovaz and J. Meldolesi},
  journal={Neurodegenerative Diseases},
  year={2007},
  volume={4},
  pages={117 - 126}
}
A turning point of research in Alzheimer’s disease was undoubtedly the discovery of BACE1, the amyloid-β precursor protein-cleaving enzyme that initiates the generation of amyloid-β, the peptide strongly suspected to be responsible for neuronal malfunction and death. Several research groups started a race to identify the best inhibitor of BACE1 activity. On the other hand, basic researchers are evaluating the changes in BACE1 expression and activity with the aim to better understand the… Expand
20 Citations

Figures and Topics from this paper

Function, regulation and therapeutic properties of beta-secretase (BACE1).
  • 73
β‐Secretase activity in rat astrocytes: translational block of BACE1 and modulation of BACE2 expression
  • 27
Toxic amyloid-β oligomers induced self-replication in astrocytes triggering neuronal injury
  • 8
Altered APP Carboxyl-Terminal Processing Under Ferrous Iron Treatment in PC12 Cells
  • C. Kim, Y. Yoo
  • Chemistry, Medicine
  • The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
  • 2013
  • 9
  • PDF
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression
  • 942
  • PDF
The BACE1-PSEN-AβPP regulatory axis has an ancient role in response to low oxygen/oxidative stress.
  • 41
  • PDF
Analysis of Alzheimer's disease severity across brain regions by topological analysis of gene co-expression networks
  • 79
  • PDF
...
1
2
...

References

SHOWING 1-10 OF 146 REFERENCES
Beta-secretase inhibition for the treatment of Alzheimer's disease--promise and challenge.
  • M. Citron
  • Medicine
  • Trends in pharmacological sciences
  • 2004
  • 200
Leaky Scanning and Reinitiation Regulate BACE1 Gene Expression
  • 83
  • PDF
...
1
2
3
4
5
...