BACE1 (β-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time

@article{Luo2003BACE1K,
  title={BACE1 (β-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time},
  author={Yi Luo and Brad Bolon and Michael A. Damore and D. Fitzpatrick and Martin Citron},
  journal={Neurobiology of Disease},
  year={2003},
  volume={14},
  pages={81-88}
}
The formation of Alzheimer's Abeta peptide is initiated when the amyloid precursor protein (APP) is cleaved by the enzyme beta-secretase (BACE1); inhibition of this cleavage has been proposed as a means of treating Alzheimer's disease. (AD) We have previously shown that young BACE1 knockout mice (BACE1 KO) do not generate Abeta but in other respects appear normal. Here we have extended this analysis to include both gene expression profiling and phenotypic assessment of older BACE1 KO animals to… CONTINUE READING

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