BACE (β-secretase) modulates the processing of APLP2 in vivo

  title={BACE (β-secretase) modulates the processing of APLP2 in vivo},
  author={L. Pastorino and A. Ikin and S. Lamprianou and N. Vacaresse and J. Buxbaum},
  journal={Molecular and Cellular Neuroscience},
  • L. Pastorino, A. Ikin, +2 authors J. Buxbaum
  • Published 2004
  • Biology
  • Molecular and Cellular Neuroscience
  • BACE is an aspartyl protease that cleaves the amyloid precursor protein (APP) at the β-secretase cleavage site and is involved in Alzheimer's disease. The aim of our study was to determine whether BACE affects the processing of the APP homolog APLP2. To this end, we developed BACE knockout mice with a targeted insertion of the gene for β-galactosidase. BACE appeared to be exclusively expressed in neurons as determined by differential staining. BACE was expressed in specific areas in the cortex… CONTINUE READING
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