BACE (β-secretase) modulates the processing of APLP2 in vivo

@article{Pastorino2004BACEM,
  title={BACE (β-secretase) modulates the processing of APLP2 in vivo},
  author={L. Pastorino and A. Ikin and S. Lamprianou and N. Vacaresse and J. Buxbaum},
  journal={Molecular and Cellular Neuroscience},
  year={2004},
  volume={25},
  pages={642-649}
}
  • L. Pastorino, A. Ikin, +2 authors J. Buxbaum
  • Published 2004
  • Biology
  • Molecular and Cellular Neuroscience
  • BACE is an aspartyl protease that cleaves the amyloid precursor protein (APP) at the β-secretase cleavage site and is involved in Alzheimer's disease. The aim of our study was to determine whether BACE affects the processing of the APP homolog APLP2. To this end, we developed BACE knockout mice with a targeted insertion of the gene for β-galactosidase. BACE appeared to be exclusively expressed in neurons as determined by differential staining. BACE was expressed in specific areas in the cortex… CONTINUE READING
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    References

    SHOWING 1-10 OF 46 REFERENCES
    BACE1 is the major β-secretase for generation of Aβ peptides by neurons
    • 705
    • PDF
    Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation
    • 725
    • PDF
    Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase
    • 718
    Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression.
    • 108
    • Highly Influential