B7S1, a novel B7 family member that negatively regulates T cell activation.

@article{Prasad2003B7S1AN,
  title={B7S1, a novel B7 family member that negatively regulates T cell activation.},
  author={Durbaka V.R. Prasad and Sabrina Richards and Xoi Muoi Mai and Chen Dong},
  journal={Immunity},
  year={2003},
  volume={18 6},
  pages={863-73}
}
T cell activation by antigen-presenting cells (APC) is regulated by positive and negative costimulatory molecules in the B7 family. Here we describe a novel addition in this family, designated as B7S1, which is uniquely anchored to the cell membrane via a GPI linkage. B7S1 is expressed on professional APC and widely distributed in nonlymphoid tissues. A soluble B7S1-Ig fusion protein binds to activated but not naive T cells. B7S1-Ig inhibits T cell activation and IL-2 production. A monoclonal… CONTINUE READING
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