B7 requirements for primary and secondary protein- and polysaccharide-specific Ig isotype responses to Streptococcus pneumoniae.

@article{Wu2000B7RF,
  title={B7 requirements for primary and secondary protein- and polysaccharide-specific Ig isotype responses to Streptococcus pneumoniae.},
  author={Z Q Wu and Abdul Qayum Khan and Yi Shen and Jerome Schartman and Robert Peach and Andrew Lees and James J. Mond and William C. Gause and Clifford M Snapper},
  journal={Journal of immunology},
  year={2000},
  volume={165 12},
  pages={6840-8}
}
The requirements for B7 costimulation during an in vivo humoral response to an intact extracellular bacteria have not been reported. In this study we immunized mice with Streptococcus pneumoniae (R36A) to determine the B7 requirements for induction of Ig, specific for two determinants on R36A, the phosphorylcholine (PC) determinant of C-polysaccharide and pneumococcal surface protein A (PspA). We show that the primary anti-PspA response, the development of PspA-specific memory, and the… CONTINUE READING

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