B7-h4 expression in human melanoma: its association with patients' survival and antitumor immune response.

@article{Quandt2011B7h4EI,
  title={B7-h4 expression in human melanoma: its association with patients' survival and antitumor immune response.},
  author={Dagmar Quandt and Eckhard Dr. Fiedler and Diana Boettcher and Wolfgang Ch. Marsch and Barbara Seliger},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2011},
  volume={17 10},
  pages={
          3100-11
        }
}
PURPOSE Cancers have developed a number of strategies to escape immune responses including the differential expression of costimulatory molecules of the B7 family. B7-H3 and B7-H4 have recently been described in different tumor entities but the relevance for melanoma has not yet been studied so far. EXPERIMENTAL DESIGN Using immunohistochemistry, B7-H3 and B7-H4 expression was studied on 29 melanoma lesions. Survival curves and log-rank tests were used to test the association of protein… CONTINUE READING

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