B7-deficient autoreactive T cells are highly susceptible to suppression by CD4(+)CD25(+) regulatory T cells.

@article{May2007B7deficientAT,
  title={B7-deficient autoreactive T cells are highly susceptible to suppression by CD4(+)CD25(+) regulatory T cells.},
  author={Kenneth F. May and Xing Chang and Huiming Zhang and Kenneth D Lute and Penghui Zhou and Ergun Kocak and Pan Zheng and Yang Liu},
  journal={Journal of immunology},
  year={2007},
  volume={178 3},
  pages={1542-52}
}
CD4(+)CD25(+) regulatory T cells (Tregs) suppress immunity to infections and tumors as well as autoimmunity and graft-vs-host disease. Since Tregs constitutively express CTLA-4 and activated T cells express B7-1 and B7-2, it has been suggested that the interaction between CTLA-4 on Tregs and B7-1/2 on the effector T cells may be required for immune suppression. In this study, we report that autopathogenic T cells from B7-deficient mice cause multiorgan inflammation when adoptively transferred… CONTINUE READING