B7-H3 and Its Role in Antitumor Immunity

  title={B7-H3 and Its Role in Antitumor Immunity},
  author={Martin J Loos and Dennis M. Hedderich and Helmut Friess and Joerg Kleeff},
  booktitle={Clinical & developmental immunology},
B7-H3 is one of the most recently identified members of the B7/CD28 superfamily of costimulatory molecules serving as an accessory modulator of T-cell response. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity. However, its precise physiologic role is still elusive, because both stimulatory and inhibitory capacities have been demonstrated. This paper summarizes the available data on B7-H3 in the… CONTINUE READING
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