B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production.

  title={B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production.},
  author={Andrei I. Chapoval and Jian Ni and Julie S. Lau and Ryan A Wilcox and Dallas B. Flies and Ding Liu and Haidong Dong and Gabriel L. Sica and Gefeng Zhu and Koji Tamada and Lieping Chen},
  journal={Nature immunology},
  volume={2 3},
We describe here a newly identified member of the human B7 family, designated B7 homolog 3 (B7-H3), that shares 20-27% amino acid identity with other B7 family members. B7-H3 mRNA is not detectable in peripheral blood mononuclear cells, although it is found in various normal tissues and in several tumor cell lines. Expression of B7-H3 protein, however, can be induced on dendritic cells (DCs) and monocytes by inflammatory cytokines and a combination of phorbol myristate acetate (PMA) + ionomycin… CONTINUE READING
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