B7-H1 up-regulation on dendritic-like leukemia cells suppresses T cell immune function through modulation of IL-10/IL-12 production and generation of Treg cells.

@article{Ge2009B7H1UO,
  title={B7-H1 up-regulation on dendritic-like leukemia cells suppresses T cell immune function through modulation of IL-10/IL-12 production and generation of Treg cells.},
  author={Wei Ge and Xiaotong Ma and Xin Li and Yafei Wang and Changhong Li and Hengxing Meng and Xiaofan Liu and Zhen Yu and Shengguo You and Lugui Qiu},
  journal={Leukemia research},
  year={2009},
  volume={33 7},
  pages={948-57}
}
Dendritic-like leukemia cells (DLLC) originating from leukemic cells could potentially induce a T cell-mediated anti-leukemia immune response. It has been demonstrated that B7-H1, a newly identified homologue of CD80/CD86, is abundant in human carcinomas and dendritic cells (DC), can exert co-stimulatory and immune regulatory functions. We demonstrated that B7-H1 was significantly expressed on AML cells and was strongly enhanced after differentiation to DLLC. Blockade of B7-H1 expressed on DLLC… CONTINUE READING

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