B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function.

@article{Tamura2001B7H1CP,
  title={B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function.},
  author={Hitosi Tamura and Haidong Dong and Gefeng Zhu and Gabriel L. Sica and Dallas B. Flies and Koji Tamada and Lieping Chen},
  journal={Blood},
  year={2001},
  volume={97 6},
  pages={1809-16}
}
B7-H1 is a recently described B7-like molecule that costimulates T-cell growth and cytokine secretion without binding to CD28, cytotoxic T-lymphocyte antigen-4 (CTLA-4), and inducible costimulator (ICOS). In this report, a mouse homologue of human B7-H1 is identified, and its immunologic functions are studied in vitro and in vivo. Mouse B7-H1 shares 69% amino acid homology to the human counterpart. Similar to human B7-H1, mouse B7-H1 can be induced to express on macrophages, T cells, and B… CONTINUE READING