B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells.

@article{Freeman1989B7AN,
  title={B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells.},
  author={G J Freeman and Arnold Stephen Freedman and J M Segil and Grace Lee and Jim Whitman and Lee M. Nadler},
  journal={Journal of immunology},
  year={1989},
  volume={143 8},
  pages={2714-22}
}
The human B cell restricted activation antigen B7 identifies an in vivo primed subpopulation of B cells that demonstrate an accelerated response to triggers of B cell activation and proliferation. The cDNA encoding B7 was molecularly cloned by cDNA expression. The identity of the B7 cDNA was confirmed by indirect immunofluorescence and immunoprecipitation of a 44/54-kDa protein from B7 transfected COS cells. The sequence of the B7 polypeptide predicts a type I membrane protein of 262 amino… CONTINUE READING
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