B4GALNT3 expression predicts a favorable prognosis and suppresses cell migration and invasion via β₁ integrin signaling in neuroblastoma.

@article{Hsu2011B4GALNT3EP,
  title={B4GALNT3 expression predicts a favorable prognosis and suppresses cell migration and invasion via β₁ integrin signaling in neuroblastoma.},
  author={Wayne Hsu and Mohd Norzaimi Che and Yaoqi Liao and Ho. Nam Chang and Chia-Hua Chen and Yu-Ming Huang and Yung-Ming Jeng and John W. J. Huang and Michael J. Quon and Hsinyu Lee and Hsiu-Chin Huang and Ming-Jung Chiu Huang},
  journal={The American journal of pathology},
  year={2011},
  volume={179 3},
  pages={
          1394-404
        }
}
β1,4-N-acetylgalactosaminyltransferase III (B4GALNT3) promotes the formation of GalNAcβ1,4GlcNAc (LacdiNAc or LDN). Drosophila β1,4-N-acetylgalactosaminyltransferase A (B4GALNTA) contributes to the synthesis of LDN, which helps regulate neuronal development. In this study, we investigated the expression and role of B4GALNT3 in human neuroblastoma (NB). We used IHC analysis to examine 87 NB tumors, and we identified correlations between B4GALNT3 expression and clinicopathologic factors… CONTINUE READING
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