B30.2/SPRY domain in tripartite motif-containing 22 is essential for the formation of distinct nuclear bodies.

Abstract

Tripartite motif-containing 22 (TRIM22) is an important antiviral protein that forms distinct nuclear bodies (NB) in many cell types. This study aims to identify functional domains/residues for TRIM22's nuclear localization and NB formation. Deletion of the really-interesting-new-gene (RING) domain, which is essential for its antiviral property, abolished… (More)
DOI: 10.1016/j.febslet.2009.05.036

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