B2 receptor-mediated enhanced bradykinin sensitivity of rat cutaneous C-fiber nociceptors during persistent inflammation.

@article{Banik2001B2RE,
  title={B2 receptor-mediated enhanced bradykinin sensitivity of rat cutaneous C-fiber nociceptors during persistent inflammation.},
  author={Ratan K Banik and Yasuko Kozaki and Juichi Sato and Lajos Gera and Kazue Mizumura},
  journal={Journal of neurophysiology},
  year={2001},
  volume={86 6},
  pages={2727-35}
}
Bradykinin (BK), which has potent algesic and sensitizing effect on nociceptors, is of current interest in understanding the mechanisms of chronic pain. BK response is mediated by B2 receptor in normal conditions; however, findings that B1 receptor blockade alleviated hyperalgesia in inflammation have been highlighting the role of B1 receptor in pathological conditions. It has not yet been clear whether nociceptor activities are modified by B1 receptor agonists or antagonists during… CONTINUE READING

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