B15 heterogeneity in East African Blacks.

Abstract

One-hundred-forty-one Blacks (135 unrelated) from Kenya and Tanzania have been tissue-typed (HLA-A, B and C loci) as part of a study of host factors involved in Burkitt's lymphoma and naso-pharyngeal carcinoma. Evidence is presented for the existence in this population of several B15-related antigens which together occur with a relatively high frequency of 30% in unrelated individuals. It is likely that these variants may include the antigens SV and perhaps Bu recently defined with population frequencies of under 1% in Caucasians. In the absence of monospecific typing sera, identification of these variants may be helped by their apparently strong association with C-locus antigens in Blacks. Recognition of these B15 variants has been largely responsible for reducing the proportion of unidentified or "blank" B-locus antigens in this population to only 6%. These findings substantiate and amplify previous reports suspecting the presence of such antigens in Blacks, and should facilitate studies of possible associations of disease with HLA in these populations.

Cite this paper

@article{Hall1980B15HI, title={B15 heterogeneity in East African Blacks.}, author={Philip Jeremy Hall and Adeera Levin and Cheryl Entwistle and Stella C. Knight and Aggrey Wasunna and Glen R Brubaker}, journal={Tissue antigens}, year={1980}, volume={16 4}, pages={326-32} }