B1 integrin activation inhibits in vitro tube formation: effects on cell migration, vacuole coalescence and lumen formation.

@article{Gamble1999B1IA,
  title={B1 integrin activation inhibits in vitro tube formation: effects on cell migration, vacuole coalescence and lumen formation.},
  author={Jennifer R. Gamble and Geeske Meyer and Leanne Noack and Jill Furze and Lisa J. Matthias and N Kovach and J Harlant and Mathew A. Vadas},
  journal={Endothelium : journal of endothelial cell research},
  year={1999},
  volume={7 1},
  pages={23-34}
}
Human endothelial cells (EC), when plated onto gels of extracellular matrix proteins such as Matrigel or collagen form capillary tubes in a process thought to mimic angiogenesis. We have shown previously that the extent of tube formation and the phenotype of the lumen are regulated by integrins (Gamble et al 1993) and lumen formation occurs through a process of vacuolization, coalescence and ultimate directional fusion of these vacuoles with the plasma membrane (Meyer 1997 et al). We now show… CONTINUE READING

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