B. abortus RNA is the component involved in the down-modulation of MHC-I expression on human monocytes via TLR8 and the EGFR pathway

@article{Milillo2017BAR,
  title={B. abortus RNA is the component involved in the down-modulation of MHC-I expression on human monocytes via TLR8 and the EGFR pathway},
  author={M. Milillo and L. Vel{\'a}squez and Aldana Trotta and M. Delpino and F. V. Marinho and L. Balboa and M. Vermeulen and S. Espindola and Nahuel Rodriguez-Rodrigues and G. Fern{\'a}ndez and S. Oliveira and G. Giambartolomei and P. Barrionuevo},
  journal={PLoS Pathogens},
  year={2017},
  volume={13}
}
Despite eliciting a potent CD8+ T cell response, Brucella abortus is able to persist and establish a chronic infection inside its host. We have previously reported that the infection of human monocytes/macrophages with B. abortus inhibits the IFN-γ-induced MHC-I cell surface expression down-modulating cytotoxic CD8+ T cell responses. MHC-I down-modulation depends on bacterial viability and results from the capacity of B. abortus to retain the MHC-I molecules within the Golgi apparatus… Expand
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