B-vitamins intake, DNA-methylation of One Carbon Metabolism and homocysteine pathway genes and myocardial infarction risk: the EPICOR study.

@article{Fiorito2014BvitaminsID,
  title={B-vitamins intake, DNA-methylation of One Carbon Metabolism and homocysteine pathway genes and myocardial infarction risk: the EPICOR study.},
  author={Giovanni Fiorito and Simonetta Guarrera and Carla Valle and Fulvio Ricceri and Alessia Russo and Sara Grioni and Amalia Mattiello and Cornelia Di Gaetano and Fabio Luiz Fernandes Rosa and Federica Modica and Licia Iacoviello and Graziella Frasca and Rosario Tumino and Vittorio Krogh and Salvatore Panico and Paolo Vineis and Carlotta Sacerdote and Giuseppe Matullo},
  journal={Nutrition, metabolism, and cardiovascular diseases : NMCD},
  year={2014},
  volume={24 5},
  pages={483-8}
}
BACKGROUND AND AIMS Several epidemiological studies highlighted the association between folate and B-vitamins low intake and cardiovascular diseases (CVD) risk. Contrasting results were reported on the relationship between folate intake and DNA-methylation. Folate and B-vitamins may modulate DNA-methylation of specific enzymes which are included in the One-Carbon Metabolism (OCM) and in the homocysteine (Hcy) pathways. The aim of the study was to evaluate whether DNA-methylation profiles of OCM… CONTINUE READING