• Corpus ID: 38306866

B vitamins increase the anti-hyperalgesic effect of diclofenac in the rat.

@article{ReyesGarca2002BVI,
  title={B vitamins increase the anti-hyperalgesic effect of diclofenac in the rat.},
  author={Gerardo Reyes‐Garc{\'i}a and Roberto Medina‐Santill{\'a}n and Flavio Ter{\'a}n-Rosales and Carlos Castillo-Henkel and Guadalupe C. Vidal-Cant{\'u} and Nadia L. Caram-Salas and Vinicio Granados-Soto},
  journal={Proceedings of the Western Pharmacology Society},
  year={2002},
  volume={45},
  pages={
          147-9
        }
}

• G. Reyes‐García, R. Medina‐Santillán, +4 authors V. Granados-Soto
• Published 2002
• Biology, Medicine
• Proceedings of the Western Pharmacology Society

B vitamins have been reported to be clinically useful alone or combined with non-steroidal anti-inflammatory drugs (NSAIDs) in some painful disorders such as polyneuropathy [1], neuritis [2], painful vertebral syndrome [3] or rheumatic diseases [4]. There is evidence that B vitamins are able to increase the antinociceptive activity of diclofenac in animals [5,6]. In humans, B vitamin preparations have been extensively used as an analgesic adjuvant combined with diclofenac for the treatment of acute lumbar vertebral pain [3,7]. However, as some negative results have also been reported [8-10], the adjuvant properties of the B vitamins complex are not completely established. In the present study, we evaluated the analgesic activity of diclofenac alone and combined with the B vitamins complex (B1, B6 and B12) in the thermal hyperalgesia test.