B vitamins and magnetic resonance imaging-detected ischemic brain lesions in patients with recent transient ischemic attack or stroke: the VITAmins TO Prevent Stroke (VITATOPS) MRI-substudy.

@article{Cavalieri2012BVA,
  title={B vitamins and magnetic resonance imaging-detected ischemic brain lesions in patients with recent transient ischemic attack or stroke: the VITAmins TO Prevent Stroke (VITATOPS) MRI-substudy.},
  author={Margherita Cavalieri and Reinhold Schmidt and Chen Chen and Vincent Chung Tony Mok and Gabriel de Freitas and Swithin S Song and Qilong Yi and Stefan Ropele and Anja Grazer and Nina Homayoon and Christian Enzinger and K. Douglas Loh and Ka Sing Wong and Adrian Wong and Yunyun Xiong and Hui Meng Chang and Meng Cheong Wong and Franz Fazekas and John W. Eikelboom and Graeme J. Hankey},
  journal={Stroke},
  year={2012},
  volume={43 12},
  pages={3266-70}
}
BACKGROUND AND PURPOSE Elevated concentrations of homocysteine are associated with cerebral small vessel disease (CSVD). B-vitamin supplementation with folate and vitamins B12 and B6 reduces homocysteine concentrations. In a substudy of the VITAmins TO Prevent Stroke (VITATOPS) trial, we assessed the hypothesis that the addition of once-daily supplements of B vitamins would reduce the progression of CSVD-related brain lesions. METHODS A total of 359 patients with recent stroke or transient… CONTINUE READING
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