B vitamin therapy for homocysteine: renal function and vitamin B12 determine cardiovascular outcomes.

@article{Spence2013BVT,
  title={B vitamin therapy for homocysteine: renal function and vitamin B12 determine cardiovascular outcomes.},
  author={John David Spence},
  journal={Clinical chemistry and laboratory medicine},
  year={2013},
  volume={51 3},
  pages={
          633-7
        }
}
Therapy to lower homocysteine with B vitamins does reduce the risk of stroke, if not myocardial infarction. The apparent lack of efficacy of vitamin therapy in most of the large clinical trials was probably determined by the failure to take account of the metabolic deficiency of vitamin B12, which is very common and often missed, and by the failure to take account of impaired renal function. Metabolic B12 deficiency is present in 20% of people over 65 years of age, and in 30% of vascular… CONTINUE READING
BETA
Highly Cited
This paper has 34 citations. REVIEW CITATIONS
Tweets
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
SHOWING 1-10 OF 15 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 44 REFERENCES

Similar Papers

Loading similar papers…