B-vitamin mixture improves the analgesic effect of diclofenac in patients with osteoarthritis: a double blind study.

@article{MagaaVilla2013BvitaminMI,
  title={B-vitamin mixture improves the analgesic effect of diclofenac in patients with osteoarthritis: a double blind study.},
  author={M C Maga{\~n}a-Villa and H{\'e}ctor Isaac Rocha-Gonz{\'a}lez and Cecilia Fern{\'a}ndez del Valle-Laisequilla and Vinicio Granados-Soto and Juan Rodr{\'i}guez-Silverio and Francisco Javier Flores-Murrieta and Miriam del Carmen Carrasco-Portugal and Juan Gerardo Reyes-Garc{\'i}a},
  journal={Drug research},
  year={2013},
  volume={63 6},
  pages={
          289-92
        }
}
According to the high consumption of the mixture of B vitamins and diclofenac in several countries, this combination has constituted a frequently used option in pain therapy from inflammatory origin. Although the evidence obtained from inflammatory pain animal models has shown the existence of analgesic synergy between diclofenac and the B vitamins mixture, the corresponding clinical evidence is scarce. A double-blind, randomized clinical trial study was designed to characterize the analgesic… 
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