B-type natriuretic peptide in low-flow, low-gradient aortic stenosis: relationship to hemodynamics and clinical outcome: results from the Multicenter Truly or Pseudo-Severe Aortic Stenosis (TOPAS) study.

@article{BerglerKlein2007BtypeNP,
  title={B-type natriuretic peptide in low-flow, low-gradient aortic stenosis: relationship to hemodynamics and clinical outcome: results from the Multicenter Truly or Pseudo-Severe Aortic Stenosis (TOPAS) study.},
  author={Jutta Bergler-Klein and Gerald Mundigler and Philippe Pibarot and Ian Gordon Burwash and Jean Gaston Dumesnil and Claudia Blais and Christina Fuchs and Dania Mohty and Rob S. B. Beanlands and Zeineb Hachicha and Nicole Walter-Publig and Florian Rader and Helmut Baumgartner},
  journal={Circulation},
  year={2007},
  volume={115 22},
  pages={2848-55}
}
BACKGROUND The prognostic value of B-type natriuretic peptide (BNP) is unknown in low-flow, low-gradient aortic stenosis (AS). We sought to evaluate the relationship between AS and rest, stress hemodynamics, and clinical outcome. METHODS AND RESULTS BNP was measured in 69 patients with low-flow AS (indexed effective orifice area < 0.6 cm2/m2, mean gradient < or = 40 mm Hg, left ventricular ejection fraction < or = 40%). All patients underwent dobutamine stress echocardiography and were… CONTINUE READING