B-type Ca2+ channels activated by chlorpromazine and free radicals in membrane of human atrial myocytes.

@article{Antoine1998BtypeCC,
  title={B-type Ca2+ channels activated by chlorpromazine and free radicals in membrane of human atrial myocytes.},
  author={Sylvestre Antoine and Thiery Lef{\`e}vre and Edouard Coraboeuf and R{\'e}mi Nottin and Alain Coulombe},
  journal={Journal of molecular and cellular cardiology},
  year={1998},
  volume={30 12},
  pages={2623-36}
}
The present study demonstrates that background or B-type calcium channel activity can be recorded in excised inside-out and cell-attached membrane patches from human atrial myocytes. In control conditions, with Ba2+ or Ca2+ as charge carrier, single-channel activity spontaneously appeared in irregular bursts separated by quiescent periods of 2-17 min, in nearly 25% of tested patches. Channel activity was recorded at steady-state applied membrane potentials including the entire range of… CONTINUE READING