B- to plasma-cell terminal differentiation entails oxidative stress and profound reshaping of the antioxidant responses.

@article{Bertolotti2010BTP,
  title={B- to plasma-cell terminal differentiation entails oxidative stress and profound reshaping of the antioxidant responses.},
  author={Milena Bertolotti and S. H. Yim and Jose Manuel Garcia-Manteiga and Silvia Masciarelli and Yoo-Jin Kim and Min-Hee Kang and Yoshihito Iuchi and Junichi Fujii and Roberta Ven{\`e} and Anna Rubartelli and Sue Goo Rhee and Roberto Sitia},
  journal={Antioxidants & redox signaling},
  year={2010},
  volume={13 8},
  pages={1133-44}
}
Limited amounts of reactive oxygen species are necessary for cell survival and signaling, but their excess causes oxidative stress. H(2)O(2) and other reactive oxygen species are formed as byproducts of several metabolic pathways, possibly including oxidative protein folding in the endoplasmic reticulum. B- to plasma-cell differentiation is characterized by a massive expansion of the endoplasmic reticulum, finalized to sustain abundant immunoglobulin (Ig) synthesis and secretion. The increased… CONTINUE READING